A method to search for long duration gravitational wave transients from isolated neutron stars using the generalized FrequencyHough

We describe a method to detect gravitational waves lasting $O(hours-days)$ emitted by young, isolated neutron stars, such as those that could form after a supernova or a binary neutron star merger, using advanced LIGO/Virgo data. The method is based on a generalization of the FrequencyHough (FH), a pipeline that performs hierarchical searches for continuous gravitational waves by mapping points in the time/frequency plane of the detector to lines in the frequency/spindown plane of the source. We show that signals whose spindowns are related to their frequencies by a power law can be transformed to coordinates where the behavior of these signals is always linear, and can therefore be searched for by the FH. We estimate the sensitivity of our search across different braking indices, and describe the portion of the parameter space we could explore in a search using varying fast Fourier Transform (FFT) lengths.Comment: 15 figure

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Continuous Gravitational-Wave Data Analysis with General Purpose Computing on Graphic Processing Units

We present a new approach to searching for Continuous gravitational Waves (CWs) emitted by isolated rotating neutron stars, using the high parallel computing efficiency and computational power of modern Graphic Processing Units (GPUs). Specifically, in this paper the porting of one of the algorithms used to search for CW signals, the so-called FrequencyHough transform, on the TensorFlow framework, is described. The new code has been fully tested and its performance on GPUs has been compared to those in a CPU multicore system of the same class, showing a factor of 10 speed-up. This demonstrates that GPU programming with general purpose libraries (the those of the TensorFlow framework) of a high-level programming language can provide a significant improvement of the performance of data analysis, opening new perspectives on wide-parameter searches for CWs

Continuous Gravitational-Wave Data Analysis with General Purpose Computing on Graphic Processing Units

International audienceWe present a new approach to searching for Continuous gravitational Waves (CWs) emitted by isolated rotating neutron stars, using the high parallel computing efficiency and computational power of modern Graphic Processing Units (GPUs). Specifically, in this paper the porting of one of the algorithms used to search for CW signals, the so-called FrequencyHough transform, on the TensorFlow framework, is described. The new code has been fully tested and its performance on GPUs has been compared to those in a CPU multicore system of the same class, showing a factor of 10 speed-up. This demonstrates that GPU programming with general purpose libraries (the those of the TensorFlow framework) of a high-level programming language can provide a significant improvement of the performance of data analysis, opening new perspectives on wide-parameter searches for CWs

Impact of signal clusters in wide-band searches for continuous gravitational waves

International audienceIn this paper we present a study of some relevant steps of the hierarchical frequency-Hough (FH) pipeline, used within the LIGO and Virgo Collaborations for wide-parameter space searches of continuous gravitational waves (CWs) emitted, for instance, by spinning neutron stars (NSs). Because of their weak expected amplitudes, CWs have not been still detected so far. These steps, namely the spectral estimation, the peakmap construction and the procedure to select candidates in the FH plane, are critical as they contribute to determine the final search sensitivity. Here, we are interested in investigating their behavior in the (presently quite) extreme case of signal clusters, due to many and strong CW sources, emitting gravitational waves (GWs) within a small (i.e., &lt;1  Hz wide) frequency range. This could happen for some kinds of CW sources detectable by next generation detectors, like LISA, Einstein Telescope, and Cosmic Explorer. Moreover, this possibility has been recently raised even for current Earth-based detectors, in some scenarios of CW emission from ultralight boson clouds around stellar mass black holes (BHs). We quantitatively evaluate the robustness of the FH analysis procedure, designed to minimize the loss of single CW signals, under the unusual situation of signal clusters. Results depend mainly on how strong in amplitude and dense in frequency the signals are, and on the range of frequency they cover. We show that indeed a small sensitivity loss may happen in presence of a very high mean signal density affecting a frequency range of the order of one Hertz, while when the signal cluster covers a frequency range of one tenth of Hertz, or less, we may actually have a sensitivity gain. Overall, we demonstrate the FH to be robust even in presence of moderate-to-large signal clusters

Direct constraints on ultra-light boson mass from searches for continuous gravitational waves

International audience\textit{Superradiance} can trigger the formation of an ultra-light boson cloud around a spinning black hole. Once formed, the boson cloud is expected to emit a nearly periodic, long-duration, gravitational-wave signal. For boson masses in the range $(10^{-13}-10^{-11})$ eV, and stellar mass black holes, such signals are potentially detectable by gravitational wave detectors, like Advanced LIGO and Virgo. In this {\it Letter} we present full band upper limits for a generic all-sky search for periodic gravitational waves in LIGO O2 data, and use them to derive - for the first time - direct constraints on the ultra-light scalar boson field mass

How effective is machine learning to detect long transient gravitational waves from neutron stars in a real search?

International audienceWe present a comprehensive study of the effectiveness of convolution neural networks (CNNs) to detect long-duration transient gravitational-wave signals lasting O(hours–days) from isolated neutron stars. We determine that CNNs are robust towards signal morphologies that differ from the training set, and they do not require many training injections/data to guarantee good detection efficiency and low false alarm probability. In fact, we only need to train one CNN on signal/noise maps in a single 150 Hz band; afterwards, the CNN can distinguish signals/noise well in any band, though with different efficiencies and false alarm probabilities due to the nonstationary noise in LIGO/Virgo. We demonstrate that we can control the false alarm probability for the CNNs by selecting the optimal threshold on the outputs of the CNN, which appears to be frequency dependent. Finally we compare the detection efficiencies of the networks to a well-established algorithm, the Generalized FrequencyHough (GFH), which maps curves in the time/frequency plane to lines in a plane that relates to the initial frequency/spin-down of the source. The networks have similar sensitivities to the GFH but are orders of magnitude faster to run and can detect signals to which the GFH is blind. Using the results of our analysis, we propose strategies to apply CNNs to a real search using LIGO/Virgo data to overcome the obstacles that we would encounter, such as a finite amount of training data. We then use our networks and strategies to run a real search for a remnant of GW170817, making this the first time ever that a machine learning method has been applied to search for a gravitational-wave signal from an isolated neutron star

Probing new light gauge bosons with gravitational-wave interferometers using an adapted semicoherent method

International audienceWe adapt a method, originally developed for searches for quasimonochromatic, quasi-infinite duration gravitational-wave signals, to directly detect new light gauge bosons with laser interferometers, which could be candidates for dark matter. To search for these particles, we optimally choose the analysis coherence time as a function of boson mass, such that all of the signal power will be confined to one frequency bin. We focus on the dark photon, a gauge boson that could couple to the baryon or baryon-lepton number, and explain that its interactions with gravitational-wave interferometers result in a narrow-band, stochastic signal. We provide an end-to-end analysis scheme, estimate its computational cost, and investigate follow-up techniques to confirm or rule out dark matter candidates. Furthermore, we derive a theoretical estimate of the sensitivity, and show that it is consistent with both the empirical sensitivity determined through simulations, and results from a cross-correlation search. Finally, we place Feldman-Cousins upper limits using data from LIGO Livingston’s second observing run, which give a new and strong constraint on the coupling of gauge bosons to the interferometer